The biological Nature of Cancer and its Therapy

By Kremer we know there is an ancient program (still fully active) in our chromosomes or genes reflecting times when there was no or little oxygen on earth, it is burning sugar fuel without oxygen, upon that there is a „younger“ system of burning sugar by oxygen. The latter is much much more effective energetically and positioned upon the former. Both systems are active and the endproduct of the first one (lactic acid) is handled into the other one (into citric acid cycle and oxidative phosphorylation or „oxidative chain“).

If there is no oxygen the first system is active only. In cancer cells 60% of the energy need is covered by this system, the other 40% are covered by oxygen burning (on the average).

Cancerous tumors consists of compounds of unicells reflecting those in the archaic ocean (of anaerobic or facultative anaerobic property), with the only intentions of growing, eating, spreading and multiplicating.

Kremer treats cancer by starting and pushing the main actors of the ‚younger‘ oxygen burning system namely the mitochondrias by means of Resveratrol, Pterostilbene(?), Cucurmin, Vitamin D3 and many other polyphenolic compounds.

By Gonzalez and Beard we know that phylogenetically the period of archaic unicells is embryologically reflected by the trophoblast in mammals and man (vertebrates). And in early pregnancy the foetus, invading the mother’s uterus, is ‚physiologic cancer‘, by exactly the 56th day of pregnancy (in humans) the character of a part of these cells changes dramatically into benign ones and the more outer placed ones are getting into apoptosis. That change of this ‚physiologic cancer‘ into „good“ tissue takes place when the pancreas of the embryo starts to work. The discovery of this was the beginning of the ‚pancreatic enzyme treatment of cancer‘ by means of mainly Trypsin and the other pancreatioc enzymes.

By Beard we know that in nature (plants and animals) in the process of multiplication asexual generations are always followed by sexual ones etc. (this is a rule!), the trophoblast is the asexual generation in mammals and men and when the trophoblast gives rise to primordial germ cells only one (or more than one in case of twins, triplets etc.) of those gives rise to the embryo the other ones travel into the back part of the yolk sac (hypoblast), multiplicating tremendously and go back into the embryonic body in which meanwhile all the organs have been formed basically structured and these ‚vagrant germ cells‘ are being spread all over the embryo’s body and remain there the rest of the individual’s life, also an adequate portion gets into the gonads being bound to meiosis to make way for the following sexual generation on the cellular level.

By Beard we also do know that the (cancerous) trophoblast is growing best in an acidic environment (now we know a tumor’s matrix-metall-proteinases like it acidic), while the upcoming pancreas on day 56th of pregnancy produces pancreatic ferments or enzymes working best in an highly alkaline juice (pH 9!).

By Gonzalez we know that these vagrant germ cells remainig all over our bodies are nothing else but the so called adult stem cells whose origin lies completely in the dark according to official science. These cells serve as repair and replacing cells for our tissues and they obnoxiously can occasionally form a „sibling“ of us: a cancerous tumor

By Simoncini we know that cancer behaves very much like fungus and according to him it is even one because he discovered that cancerous compounds dissolve quite well by alkalizing their extracellular interstitial space moreover he states that fungus can represent itself in so many forms science does not know yet. The best natural antimycotic is Sodiumbicarbonate.

Official oncology admitts there is always fungus with cancer but it is a secondary fungal infection. Simoncini maintains the other way, there is always fungus in the first place! I am deeply convinced Simoncini is right because there are so many positive therapeutic reports on cancer on his homepage these can’t all be faked.

Simoncini observed that the links between cancer cells get disrupted easily by alkalinity and the immune system can deal much much better with singular cells but a compound (tumor), here it is at hand to combine alkalinization (Simoncini) with pancreatic enzymes (Gonzalez and Beard).

C O N C L U S I O N OF THE CONCLUSION

Cancer cells are acid machines, this counts first of all for solid tumors (not necessarily in lymphomas) these are producing abundant amounts of lactic acid because 60% of their energy need is fed by sugar burn without oxygen. That acid on the one hand is being exported in the extracellular space right outside the cell membrane and sets a remakable activating stimulus to the matrix-metallo-proteinases that melt away the healthy surrounding tissue of the cancer patient (or the uterus tissue of the mother in case of pregnancy) and on the other the huge acidity is buffered in the cell’s inside very effectively.

The acid export can be blocked amongst other chemicals by commonly prescrib ed Amilorid .

First of all cancer cells do have to stand their own acidity that’s why those are intracellularly calibrated highly alkaline! This is happening through buffering by Sodiumbicarbonate, the crucial point is that NaHCO3 is a so called ‚open buffer‘ means the carbonic acid molecule which is formed by the buffer reaction (HCO3- + H+ = H2CO3) falls apart immediately into water and carbondioxide and therefore gone thus the buffer can keep a very high alkalinity without being used up too quickly. The falling apart of carbonic acid is actually a spontaneous reaction BUT accelerated by the intracellular enzyme Carboanhydrase 10 000 000 times thus the intracellular pH of the cancer cell is definitely steered by CA.

The acid buffering inside the cell can be blocked by inhibiting carboanhydrase by Acetazolamide (Diamox e.g.).

The acidic interstitial space and the further environment of a cancerous tumor has to be alkalized but not mainly by Sodiumbicarbonate but by the salt of a weak organic acid like citrat, lactate, acetate etc.

The strategy implies the cancerous tumor‘s extracellular alkalinization by intake (or iv) of organic salts and acidification intracellularly by inhibition of Carboanhydrase (and ev. the acid exporting membrane carrier).

Eventual additional application of pancreatic enzymes, Resveratrol, Cucurmin, Vitamin D3 (very important) and many polyphenolic compounds (PAC etc.) . Healthy cells are only effected minimaly (acceptable intracellular pH decrease) because they are depending mainly on oxygen burn.

ETC. !!!!???

Gonzalez’ cancer theory is being based on too scientific disciplines, namely Neurophysiology (very logical and very unknown) and Embryology, first we focus on Embryology.

www.dr-gonzalez.com

Already in the fading 19th century the Scottish embryologist Dr.John Beard found out that the embryo or very early fetus invades the maternal tissue like cancer. The fascinating fact about this is that the very early embryo does not only behave like cancerous cells in a way but IS cancer indeed, using e.g. the identical matrix metallo-proteases to dissolve the tissue of the uterus, this is latest research as well, please see:

http://www.scientificamerican.com/article.cfm?id=cancer-clues-from-embryos

Thus we have too accept the weird fact that the early fetus is cancer, it invades the uterus as primary tumor, but this is the way of nature UNTIL the 56. day of pregnancy (in humans), this is when the fetus‘ pancreas starts to work, this is the day when pancreatic enzymes appear in the fetal blood the first time;

From this moment on the development of the „outer“ fetal cells take an orderly differentiating course changing into trophoblastic cells (first Syncytiotophoblast, later the complete placenta) to nurture the fetus.

This tremendous change in the character of the fetal cells must be caused by the newly upcome of pancreatic enzymes!

For Beard it became clear later that it’s the pancreatic enzymes trypsin and chymotrypsin (e.g. trypsin is being used in biology to dissolve strongly linked groups of cell in vitro, moreover in cleansing agents like wash powders etc.). Trypsin (an endopeptidase) splits peptides usually behind the aminoacids Arginine and Lysine which are both known for their antitumorous properties.

In modern physiology it has been known for the longest already that there is no strict functional separation between the exocrine and endocrine pancreas, means there is also a significant amount of trypsin and chymotrypsin circulating in one’s body disarranging probably upcoming ensembles of tumor cells.

So first of all cancer seems to be some kind of pancreas insufficiency! Strange, isn’t it?

Why do cancer cells have these embryonic properties because cancer does not exclusively take place in a woman’s uterus only, no, cancer takes place EVERYWHERE in the body!

There are two cell-aggregations in the first days of pregnancy called the inner and outer cell mass.

Out of common morula, followed by blastula, that changes in humans directly into the liquid filled blastocyst which shows on the fifth postfertile day a round convexed herd of cells inside prostating into the cyst, the inner cell mass.

The other cells (called the outer cell mass) tend somehow to becoming a cell arrangement called the trophoblast (the later placenta or chorion) and the „inner“ cells intent being one called the embryoblast, but there is hardly a difference between these ones in the beginning.

The 6th day the embryo sprouts out of a single cell of the inner cell mass, after all the other cell have continuously developed out of the fertilized egg, this fact gives way to the insight that the throphoblast is there from the beginning and the embryo comes out of it. Thus the trophoblast gives „rise to the embryoblast.“ (Gonzalez)

ATTENTION!

When the embryoblast further starts to develop into the epiblast (a complete microcellular arrangement of the later human body) and the hypoblast (e.g. yolk sac etc., bound to degenerate later), the BUNCH OF THE REST OF CELLS OF THE INNER CELL MASS get aside and travel to the „back margin“ of the yolk sac remaining there and multiplicate several days, these cells are so called migrant or vagrant primordial germ cells and these are not somatic because of their coming from the trophoblast.

At the beginning ot the fourth week of pregnancy these primordial germ cells start to move on again, this time in a spirallike motion through the whole of the later human body (Epiblast) finally ending up in our reproductive organs (embryonic stem cells - ESC) being developed into sperms and eggs later.

BUT! During their journey to the genitals through the whole of the later body to be formed, almost everywhere a portion of germ cells STOPS migrating and remain where they are for serving from now on as repair or replacing cells the rest of our life.

AND THESE CELLS ARE OUR ADULT STEM CELLS, nobody in official science wants to know that, but this is the truth. And according to Beard and Gonzalez it’s those cells only that can become cancerous. Again modern science accepts in the meantime that only one or two cells out of several hundreds of tumor cells are definitely responsible for a tumor’s growth, please see:

http://www.cancer.med.umich.edu/news/stemcell.htm

And changes in the milieu around these cells in our body make those vagrant germ or adult stem cells to develop what we call cancer later in life, some strange stimuli drive them into a trial of (pseudo)meiosis (by chronic infection esp. fungal one, mechanical irridation, lack of trypsin, etc.?) with a totally disarranged set of chromosomes (up to 92 ones and even more fractured pieces) to form a trophoblast without success, only able to grow, invade and metastasize …

The basic line of Beard and Gonzalez ist that cancer only can come from adult stem cells which are identical with the vagrant embryonic germ cells that are actually trophoblastic cells dwelling in our bodies the whole of life and serving as supply for tissue replacement.

Modern molecular biology says clearly that only undifferentiated cells are able to divide and duplicate themselves.

As you know from university medical studies there is a part of the vagrant germ cells that travels into the gonades as primordial germ cells bound to undergo meiosis to form eggs and sperms (haploid chromosomal setting), and after fertilization a trophoblast in a woman’s uterus, this is their natural healthy way.

AND NOW PLEASE LISTEN!

The other portions of these identical vagrant germ cells that remain in the early embryonic body outside the gonades are n o t supposed to undergo meiosis to form new life, as mentioned above thea serve as source for tissue renewing the whole of our life. BUT for some reason(s) some of those are trying in abundant cases an

UNSUCCESSFUL UNDERTAKE OF FORMING A TROPHOBLAST

outside the gonades at the wrong place and at the wrong time, and

THIS IS CANCER !

Wiliam Donald Kelley, the ingenious dentist, in his post mortem edited book ‚Curing the Incurable‘ expresses out of pure clinical observation and knowing Beard’s book of 1911, that the basis for cancerous development are tissue damage, presence of ectopic germ cell(s) and female hormones locally and a pancreas insufficiency generally with reduced amounts of trypsin and chymotrypsin circulating (chapters 3 and 4).

http://www.amazon.de/Cancer-Incurable-Without-Chemotherapy-Radiation/dp/0970429002/ref=sr_1_1?s=books-intl-de&ie=UTF8&qid=1414573496&sr=1-1&keywords=kelley+curing+the+incurable#reader_0970429002

Or putting it in actual terms: ‚Damaged tissue‘ is a fairly oxidized microenvironment, acidic, lacking informing photons, slime, transfected by fungus, in which ‚ectopic germ cells‘ (senescent stem cells) hardly can survive, fungus separates those completely from any infomative connection with the body, the cell is „on its own“, the chromosomal setting changes, the reproductive program starts to secure the survival of the new cellular being. Because of the fungus supporting acidity eventually circulating active proteolytic pancreatic hormones are being inactivated, this circumstance may be accentuated by a general ‚pancreas insufficiency‘. The ‚female hormone(s)‘ human chorionic gonadotropin (hCG), reflecting the luteinizing one (LH) besides others are expressed by the onsetting cancer (Acevedo) to defend rejection by the immune system.

http://www.ncbi.nlm.nih.gov/pubmed/8620425

Those adult (later senescent or and possibly precancerous) stem cells are primordial germ cells immigrated from the inner cell mass at the 4th postfertile week. This is the reason why they have to go on trying to deliver new cells for damaged or ageing organs or form new life (by undergoing recombination and chromosomal change). They have developed for that. This is their natural and physiologic mission.

And if they change theit chromosomal setting they have to face the body’s immune reaction to be dispelled thus they produce analogous hormones to avoid this, first of all human chorionic gonadotropin (hCG) reflecting the luteinizing hormone (LH) besides others like FSH or TSH.

These adult stem cells and those (ectopic) vagrant germ cells are identical they serve as tissue suppliers in the whole of the body for the rest of our life. Telomerase is only active until the end of differentiation of the organs in different fetal tissues (e.g. heart 12th week, brain and kidneys 16th week, liver and testicles 21st week).

Thus adult stem cells do have a Hayflick limit (Blasco), their forerunning embryonic ones do not and thus the germ cells of adult males and females as well.

Cancer is trophoblastic cells they feed nobody (except fungus?), there is a philosophic – spiritual link, fungus is philosophically often seen as ‚manifested negativity‘ in our organism, it’s logical that ‚strongest negativity‘ (cancer) could grow out of ‚negative‘ fungus.

I suspect, our adult (senescent) stem cells (vagrant ectopic germ cells) are being enslaved by fungus to support it‘s growth by delivering the (lactic) acidic milieu fungus likes so much to grow …

Neurophysiology, another part of Dr. Gonzalez‘ approach (the basic idea is very simple) refers to our autonomic nervous system, it consists of 2 parts, Parasympathicus or Vagus or 10th brain nerve and the Sympathicus.

All humans are either dominated by one of these parts or in a mixed (more or less balanced) state. The phylogenetic older part is the vagal (parasympathetic) one, inducing relaxation, calmness, sleep, recreation, tissue replacement, low RR and pulse etc. and the other „younger“ one is the Sympathicus mediating activity, aggression, fight or flight, facing problems, high RR and pulse etc.

The system out of this is very simple and correlates widely with old eastern ones.

People being dominated by the sympathetic system develop solid tumors (colon, stomach, esophagus, kidneys, liver, lungs etc.) and

NOW PLEASE LISTEN:

People that are being dominated by the parasympathetic system receive diffuse cancer types (e.g. myeloma, lymphoma, plasmocytoma, leucosis or leukemia, generally spoken these types called ALL, CLL, AML, CML)

And consequently persons having a mixed state of the autonomous nervous system tend to get no cancers but if, they are getting both forms somehow diminished (maybe Hodgkin or Non-Hodgkin?)

This is the simple truth behind cancer disposition but in detail very difficult to figure out.

The therapeutical consequence is nothing else but feeding „sympathetic“ cancer patients with solid tumors by energetically soft structured food, means the have to have a pure vegetarian or even better vegan diet!

AND NOW PLEASE READ CAREFULLY AGAIN, THIS IS EVEN SHOCKING!

Parasympathetic People having a diffuse type of cancer are born carnivores, they have to have an (almost) pure red meat diet!

If you can’t believe look to Dr. Gonzalez homepage:

www.dr-gonzalez.com

One finds generally enough evidence explaining this (strange) fact. I personally believe this is true because I was engaged in Macrobiotics several years, moreover a person I had been knowing for decades turned (by the influence of his mate, a nurse) into vegetarianism and developed lymphoma!

It’s so weird they have to eat lots of meat, I put it in red, it hurts a little bit the eyes, thus one will be keeping it in mind forever.

As I told in detail it’s not that simple because people are often mixed types but it’s the type of cancer that is guiding the dietary recommendation. The modern name of this kind of medical science and therapy is Metabolic Typing, it’s just another word and Gonzalez (he got it from his teacher Kelley) figured out the deepest therapeutical consequences.

The cells forming normally the orderly placenta are nothing else but those vagrant germ cells taking place in the embryonic gonades during early fetal development, going into recombination and meiosis, later being connected with another gamet (sperm or egg) during and by sex and form the trophoblast of the new fetus and this physiologically „cancerous“ trophoblast turns into orderly development to form the placenta AFTER THE 56th DAY OF PREGNANCY or fertilization (literature not fully clear on that).

The root of the problem ist the continuous ongoing shortening of the adult stem cells‘ telomeres by each division. These are in charge of repairing and replacing impaired tissues whenever necessarry (harm, inflammation, natural cell death by ageing).

In the course of life the shorter a stem cell‘s telomeres get the more incomplete and impaired cellular differentiation of its offsprings in the process of periodic natural cell renewal or damaged tissue repair. By ongoing cell divisions and telomeres‘ shortening the genetic program of celluar renewal is losening ist accuracy more and more, replacement of gone well differentiated proper functioning cells by dys- and further anaplastic ones (e.g. villous polypes, basalioma etc.).

Before this is happening such cells should get apoptotic but for some reason in so many cases they don’t!

Further regression leads finally (via irregular recombination as latest step of „differentiation“) to solid cancerous tumors without any signs of differentiation detectable. Cancer is impairment of cellular differentiation. Dividing cells are always on the glycolytic metabolic pathway of ATP-production to prevent oxidative damage of the nucleic spindle by oxygene radicals from respiratory burst in oxidative phosphorylation (usual energy source in metabolic active non-dividing cells) (Brand).

http://www.ncbi.nlm.nih.gov/pubmed/9387096

http://www.ncbi.nlm.nih.gov/pubmed/9141507

Glycolytic pathways imply the production of lactic acid as endproduct to be discharged by the cell (monocarboxylate transporter) causing an acidic interstitial environment fungus likes a lot. So to say while trying to repair something damaged, those cells are feeding the main cause of metabolic damage: fungi. And providing those with lactic acid they turn into glucose or other sugars.

Fungi are the most developed microbial beings, creating communities of cells apparently showing „social“ behavior thus cells helping each other in case of food shortage or if one’s damaged. In cancerogenisis fungi seem to infect and enslave senescent stem cells by blocking their apoptotic triggers and programm (e.g. p53 etc.).

The Italian physician Dr. Tullio Simoncini counteracts this by delivering large amounts of sodium bicarbonate to turn lactic acid into the harmless sodium lactate and neutralizing H+ cations to carbonic acid with sodium bicarbonate (buffer reaction).

Fundamentally is valid if you deliver lactate (it’s the anionic salt of lactic acid, normally sodium lactate) you have a buffering effect, if you deliver it as acid, you have an acidifying effect, normally the sodium bicarbonate molecule is automatically delivering its dissociated sodium anion to turn lactic acid into sodium lactate, the acidic H+ will be linked via sodium bicarbonate to H2CO3 and fall apart by Carboanhydrase into CO2 and H2O, better you do not deliver lactic acid but its salt thus the body can spare this reaction. There are certain preparations carrying lactic acid and its salt by adjusted pH (e.g. Canesten).

Concerning uric acid, it has been found out recently that you should not lower uric acid or urate in the blood because it acts with Vitamin C and E and Provitamin A as first-line-free-radical-scavenger-defence! Lower it only if someone has gout attacks! (Mikami et al.)

http://www.ncbi.nlm.nih.gov/pubmed/10625215

http://www.ncbi.nlm.nih.gov/pubmed/10730822



Besides treating cancer patients by pancreatic enzymes and food Doctors Kelley and Gonzalez do have a third therapeutic column namely ‚liver-detoxification‘. Let’s go now to this third basic approach concerning their theory and method:

The 3rd column is (liver) detoxification, whatever has to be broken down being eliminated by the kidneys, sweat out by our skin or breathed out via the lungs, or grown out by our hair … is definitely happening in the liver. So it’s tantamount to support our livers for leading a healthy life. As I told you already the vagus is promoting sleep, recreation, relaxation, detoxification etc.

What Gonzalez has gotten by his ingenious teacher the dentist Dr. William Donald Kelley is really incredible: it’s the coffee enema

Yes you did hear rightly, taking coffee up the rectum it has a complete different effect than the oral way, this has to do with the autonomic innervation that differs in the lowest part of the body, you‘re having in your small pelvis (little sidestep: ruled energetically by Muladhara cakra acc. to Hindu cosmology)) a dominating vagal (parasympathetical) innervation because the vagus is the very elder brother of the latter sympathicus (by the way this is the reason why we have to face very archaic feelings when having sex with the lowest body-entrances, it’s actually the lust of jellyfish, molluscs and worms).

By taking rectally (saw a DVD with Gonzalez, he stated he never would take coffee through the mouth because he never wants to get cancer in his life) coffee is stimulating tremendously the parasympathicus, leading to total vagal activation of the liver that is almost immediately dumping all the junk there is into its bile ductuli and the gall bladder and finally via the choledochus into the duodenum.

The coffee enema has been discovered by the magnificent and unforgetable Florence Nightingale in the Krim War (1853 -56), for evident waring reason they had nothing left for treating the wounded but large amounts of coffee beans, there was no intravenous infusion then, so they applied it as enemas and many of the death ridden soldiers improved because it turned on their liver function and this fact turned out to have been life saving in so many cases.

Gonzalez mentions that the coffee enema was in the Merk Manual (American doctor‘s handbook) up until the nineteen-twenties, then it got removed (Gonzalez‘ cancer patients are doing coffee enemas several times a day).

Now we have finished Dr. Gonzalez, next will be Dr. Siomoncini.

Normal oncologists say there is always cancer with fungus because fungus likes being in the environment of cancerous cells, thus cancer patients have usually a so called secondary fungal infection, Simoncine says it’s the other way round, first the fungus and thereafter the cancerous fungus. He proves this by using a very cheap and strong natural alkaline antimycotic substance called sodium bicarbonate, saying cancer cells are fungal cells and NaHCO3 is doing nothing else but dissolving the loose bounds between these cells that are linking those together and the immune system of the patient can easily deal with singular cancer or fungal cells.

I am deeply convinced Dr. Simoncini believes what he sayse, look at his homepage. Can this all be a lie?

www.curenaturalicancro.com

Thus look at his protocols and see the evidence, Dr. Simoncini states cancer is a fungus and NaHCO3 a very strong and cheap antimycotic and it destroys the cancer! Not much about, that’s all. But (I believe) the truth behind is on the biochemical level more complicated and so far very fascinating as well. Evidently for Simoncini the most important factor is that it works and the theory is more or less of little importance. He is right NaHCO3 is a good antimycotic, just make a salve or creme out of it (your pharmacist should puffer it at pH 7,5) and put it on the spots between your toes, the fungus vanishes … But why does it work?

We know from studies by Australian scientists that 65% (and above) of a cancer cell’s energetical need is being fed by anaerobic glycolysis in the cytosol (Guppy et al).

http://www.ncbi.nlm.nih.gov/pubmed/11988105

This means a very big lot of lactic acid is being produced all the time, this is the reason why the intracellular pH of a cancer cell is very alkaline for to stand all the acidic outcome of anaerobic glycolysis. The cancer cell is permanatly shufflings lots of Na+ and HCO3- ions into itself and is putting the equivalent amount of H+ ions and lactic ions out of the cell. Thus a cancer cell‘s inside is buffered on a very high alkaline level and because of its very high acidic output a tumor’s interstitial space is very acidic (0,5 lower than inside on the average). Untill recently for technical reasons the pH-values of tumors were taken from the interstitial space only, therefore came the general conviction cancers be through and through acidic by their nature.

But the truth is : Cancer cells are alkaline in the inside and acidic in their nearest vicinity (the so called tumor mass), thus cancerous tumor’s cells are (very) alkaline and a tumor’s interstitial space is (very) acidic.

In the process of acid buffering the cancer cell is acting very clever by achieving buffering of 2 acidic H+ ions by 1 molecule of dissociated sodium bicarbonate (Na+ HCO3-), the 1 Na+ ion „in“ is being traded against 1 H+ ion „out“ (this happens with potassium also but to a much lower extent compared to normal cells, cancer cells are known to have lots of sodium in the inside).

The putting out of an acidic H+ ion is a simple thing compared to that what the inshuffled HCO3- ion is doing, immediately after entering the cancer cell’s cytosol it is buffering 1 H+ ion forming spontaneously H2CO3 (carbonic acid) and H2CO3 is being split in H2O and CO2 by the enzyme carbonic anhydrase, both molecules are diffusing away (or being transported) and have no longer any acidifying effect and thus the buffering has been completed (too much CO2 will be finally breathed out by the lungs and H2O by the kidneys and skin).

Now we have to make a little sidestep , we look into well known textbooks in biochemistry and physiology (Karlson and Ganong)

Karlson (11. Auflage, 1980) Seite 311: (Anm.: bei Säuren ist pK gleich pH, wenn das dissoziierte Anion in gleicher molarer Konzentration vorliegt wie das nichtdissoziierte Molekül)

Zitat : '...Der pK-Wert der Kohlemsäure (1. Stufe), beträgt 6,1; bei einer nichtflüchtigen Säure wäre in dieser Gegend beste Pufferwirkung zu erwarten. Da aber CO2 flüchtig ist und durch die Kohlensäurehydratase stets ein Gleichgewicht zwischen CO2 und H2CO3 eingestellt wird, ist die effektive H2CO3-Konzentration vor allem von der Kohlendioxid-Spannung abhängig. ...'

Ganong (deutsche Ausgabe, 4. Auflage, Springer Verlag, Berlin Heidelberg New York 1979) Seite 651 links unten:

Zitat : ‚ … Wird dem Blut H+ zugesetzt, dann nimmt HCO3-, dessen Konzentration zusätzlich durch die Niere reguliert wird, ab, während vermehrt H2CO3 entsteht. Würde diese zusätzliche H2CO3 nicht in CO2 und H2O übergeführt und das CO2 in der Lunge abventiliert, so müßte die H2CO3-Konzentration ansteigen. Wäre z.B. die zugesetzte H+ Menge ausreichend gewesen, um das Plasma-HCO3- auf die Hälfte absinken zu lassen, dann wäre ein pH-Abfall von 7,4 auf 6,0 die Folge. In Wirklichkeit wird aber nicht nur die gesamte zusätzlich gebildete H2CO3 entfernt, sondern der H+ Anstieg regt auch die Atmung an; dies bewirkt einen Abfall des pCO2 so, daß zusätzlich H2CO3 entfernt wird. Das pH würde daher im vorliegenden Beispiel nur auf etwa 7,2 abfallen (Abb. 40.2). Die Reaktion CO2 + H2O = H2CO3 verläuft in beiden Richtungen langsam, wenn das Enzym Carboanhydase nicht anwesend ist. Im Plasma fehlt Carboanhydrase, in den Erythrozyten ist sie jedoch reichlich vorhanden …‘

Finally see

Garrett Reginald, Charles M. Grisham: Biochemistry. (International Student Edition). 4. Auflage. Cengage Learning Services, 2009, ISBN 978-0-495-11464-2, S. 394,

Zitat : ‚… Carboanhydrase ist ein Enzym, das sehr schnell katalysiert: Sie kann bis zu 106 Moleküle Kohlenstoffdioxid pro Sekunde hydratisieren und beschleunigt die Reaktion auf das 107-fache. Ihr kcat-Wert liegt bei 1.000.000 pro Sekunde. …‘

Says the bicarbonate-buffer used up by half and left on it‘s own will cause a pH in the blood of around 6,1. But this would be far too acidic and not compliable with life because we know the pH of the blood is being constantly kept between 7,35 and 7,45 (or more exact 7,38 – 7,43), ICUs are normally dealing with between 7,35 and 7,45. If bicarbonate alone only could keep very acidic levels in our body what does happen really in our metabolism or even in cancer cells having a pH far beyond 7,5 (Kremer even says, „cancer cells are somehow fixed in alkalinity“), but how is the bicarbonate-ion doing this?

Just one shall add one and one and one … It’s quite simple, maybe too simple? Nature’s work appears somtimes surprisingly simple.

The solution for the high-pH-buffer-capacity of the bicarbonate-ion (HCO3-) lies in the acceleration of the natural splitting or „falling apart“ of the carbonic acid-molecule (H2CO3) into water (H2O) and carbon dioxide (CO2) by 10 000 000 times this fact is being achieved by a „very old magic“ exclusively intracellular and surface localized bound enzyme called carbonic anhydrase.

Now we have to make another little sidestep into a well known textbook of toxicology (Casarett and Doull’s) on page 244 the action of a carbonic anhydrase inhibitor (acetazolamide) is described and it mimics CO2 –intoxication.

Casarett and Doull's Toxicology (4th Edition 1991, Pergamon Press), Seite 244:

Zitat : '...In some respects the CO2 environment mimics the effects of acetazolamide. ...'

If you are blocking the effect of carbonic anhydrase the falling apart of carbonic acid will be 10 000 000 times slower, meaning you are getting a lot of carbonic acid in your cells falling apart definitely slower which is actually a carbonic acid intoxication because (left on it‘s own) the pH might get down to a point which is not compliable with life, if dosaged properly.

From my point of view Simoncini is just overwhelming or overdoing the capacity of a cancer cell’s carbonic anhydrase (CA) by putting lots of sodium bicarbonate into the system, the majority of formed carbonic acid (H2CO3) is falling apart10 000 000 times slower than it should for „normal“ function and we have a carbonic acid intoxication of the cancer cell (substrate inhibition)!

But there is a firetest, the same effect should be produced by acetazolamide which mimics CO2-intoxication (see above) because this substance blocks or inhibits carbonic anhydrase (CA), thus we should have through application of acetazolamide (in a way) the same deteriorating effects on cancer cells as while giving high dosages of sodium bicarbonate. And this is definitely the case, I found a Chinese study showing a decrease in growth of primary tumors and metastasis (see attached study) under application of CA with or without NaHCO3.

Int. J. Mol. Sci. 2007, 8, 229-240, 13 March 2007 http://www.mdpi.com/1422-0067/8/3/229 or www.mdpi.org/ijms/ or http://www.mdpi.org

"Effects of Acetazolamide Combined with or without NaHCO3 on Suppressing Neoplasm Growth, Metastasis and Aquaporin-1 (AQP1) Protein Expression"

Zitat aus Abstrakt: '...Results showed that acetazolamide alone could sharply reduce the number of lung metastasis and primary tumor growth, and appeared in a dose-dependent manner. Acetazolamide significantly inhibited carbonic anhydrase activity in tumor tissue. ...'

This implies very simple approaches in treating cancer, imagine prescribing daily acetazolamide (Diamox) and Sodiumbicarbonate (iv or also orally), you could check a patients base excess and adjust him to a maximum level, moreover there is eventually additional Amilorid possible that blocks the acidic H+ ions output of the cancer cell. A dangerous loss of Magnesium and Potassium could be prevented by daily intake of moderate amounts of Sodium(Na+)Potasium(K+)-Aspartate (Tromcardin) or K/Mg-Orotate (Magnerot).

There are some things more to say to this because as you know the devil resides in the detail, this is the basics though.

Last step is to formulate a unifying model in theory and therapy

Although the main challenge will be, as I mentioned, to formulate the unifying ultimate model in thinking (theory) and practicing (therapy), e.g. Gonzalez (Kelley, Beard) found out that the enzyme trypsin (ev. Chymotrypsion also) is dissolving and digesting cancerous tumors, by reading textbooks in physiology you see that the pancreatic juice getting into the duodemum has a pH pf 9 (!!) means the more alkaline the environment the better it works. Though we know highly dosed bicarbonate is actually acidifying the inside of tumor cells by overstraining carbonic anhydrase (substrate inhibition) but the outside is getting probably more alkaline and this supports the action of trypsin, consequently Simoncini’s and Gonzalez‘ approaches should be evidently combined (bicarbonate plus digestive enzymes like trypsin etc).

As I told already biologists are using trypsin to dissolve links between cells in cellular compounds in vitro, moreover (ironically) trypsin appears in many washing powders but not in cancer medicine …

There are conclusions having been thinking it over for years now, the 3(4) theories (Burzynski runs somehow with the others, he should fit in too):

Kremer :

More than 2,1 billions years ago there was no volatile oxygen (or very little) on earth, in the archaic ocean then groups of primitive unicells were floating around, these had only few basic intentions to survive and stay alive namely eating, growing and multiplicate themselves. This behavior is being ruled by probably the first genetic program nature ever developed, it’s an old archaic one, therefore called Genome A and it burns sugar without or very little oxygen;

later when photosynthesis came up oxygen appeared in huger amounts on earth nature developed unicells (predecessors of our bacteries) able to utilize oxygen getting much more energy out of the burning of sugar (later these inclusions were called mitochondrias). This bacterial genetic program is therefore called Genome B.

In a unique creational act the archaic and prebacterial cell joined somehow, these prebacteries entered the cytoplasm of the archaic unicells enabled those to utilize oxygen for burning sugar, but also the archaic Genome A remained active but dominated and overruled successively by the oxygen utilizing Genome B. This is called the act of Cell Symbiosis and laid the foundation to the further development of all life on this planet.

But we do have to be aware of the fact that the chromosomal setting of these early cellular beings might have been quite dissimilar to ours because it is also the basis for nowadays insects‘ ones that are very different from humans.

In all living beings both gentic systems Genome A+B are still present and at work and genome B is the dominating one. What Kremer says is just as this simple, through certain unpleasant influences our mitochondrias get weaker and weaker and when this weakness reaches a certain point Genome A takes over and we have cancer. Cancer cells are not bad they just are doing what they need to do for surviving.

According to Dr. Kremer, living in Barcelona for some reason, cancer is dominating Genome A caused by mitochondriac failure (Mitochondriopathy). All the permanent discoveries of oncogenes is (acc. to him) some kind of bullshit because each newly discoverd oncogene is nothing else but a gene or genes of Genome A.

Therapeutic consequence „GET THE MITOCHONDRIAS BACK TO WORK AGAIN“!

Kremer says, if the mitos get into trouble the cell’s ability to utilize oxygen diminishes more and more (although enough oxygen could be around creating a condotion called „pseudohypoxia“), in fact of the cells need for sufficient ATP these are forced to strengthen the anaerobic path for ATP-production but for the price of worsened energy economics and decreased metabolic complexity, de(!)differentiation of the cell takes place until it reaches the point of being cancerous with full activated and dominating Genome A.

Kremer is being treated by his followers like a guru, he discovered a big part of the truth though not all.

There is a fourth guy on the block, Dr. Burzynski in Texas, I put him in parentheses, about him I know the least, according to him, cancer patients have a certain lack of peptides in the blood and urine. That’s why they are getting it (a peptide is an amino acid chain of 2 to 50 AA), Burzynski is replacing the missing peptides (which are part of a „second immune system“) that kills the cancer cells.

In the beginning of a treatment the amino acid and peptide pattern in the patient’s blood and urine is detected, because this reflects the genetical make up of a certain cancer, out of these findings the substitution of the „right“ peptides can be applied orally or intravenously, ideally the uncontrolled divisions of the cancer cells are going to be stopped by blocking the oncogenes that are many in all the different cancer types.

Possibly this treatment is blocking those groups of genes which are belonging to Genome A (Kremer).

www.burzynskiclinic.com

Sympathicus and the immune system are phylogenetically young compared to parasympathicus (vagus) and the ground system and its regulation (Prof. Pischinger) which is called the Extracellular Matrix (ECM) and there is even described an intracellular system of units of life as Association/Induction Hypothesis (Ling).

www.gilbertling.org

Saying peptide chains can be totally folded or unfolded (not more or less), presenting different electrochemical loads (+ or -) to dipolic water molecules and neighbouring ions thus steering the cell’s vital and functional activity by this (in cooperation with ATP and other ‚inducers‘).

Perhaps the Burzynski therapy does work specifically on these systems (Kremer’s method seems more unspecific).

The decisive point is that carbonic anhydrase accelerates the splitting of carbonic acid (H2CO3) into Water (H2O) and carbon dioxide (CO2) and thus by CA nature can adjust very precisely the required pH, I mean CA can more or less accelerate it and even the other way round (forming H2CO3 out of H2O and CO2 if necessary), because of this unique property sodium bicarbonate is called „open buffer“, to my knowledge the only one in metabolism (but maybe something similar can happen with H2SO3 or H2S in the process of so called chemolithotrophy).

By inhibiting (acetazolamide) CA or putting huge amounts („overdose“) of sodium bicarbonate the splitting rate of H2CO3 decreases because CA cannot do sufficiently its job any longer and thus intracellular acidification takes place (carbonic acid intoxication).

Extracellularly there is acidity anyway because there is no CA in the interstitial space, this is the reason why the intercellular space (interstitium) generally tends to be too acidic, making way to virtually all chronic diseases (incl. cancer).

In my younger doctor years I did these things although not understanding the details then, I saw liver metastatic herds getting smaller (a little bit) by sodiumbicarbonate iv infusions with pancreatic enzymes (very high risk of allergic shock), moreover I made the experience that such patients are being ignored by the specialists in the hospitals and die rather fast after a slight improvement was detected. Nowadays the system has become too rigid to do such things in a relaxed way.

By Kremer we know there is an ancient program (still fully active) in our chromosomes or genes reflecting times when there was no or little oxygen on earth, it is burning sugar fuel without oxygen, upon that there is a „younger“ system of burning sugar by oxygen. The latter is much much more effective energetically and positioned upon the former. Both systems are active and the endproduct of the first one (lactic acid) is handled into the other one (into citric acid cycle and oxidative phosphorylation or „oxidative chain“).

If there is no oxygen the first system is active only. On the avereage in cancer cells 65% to 70% and even more of the energy need is covered by this system, the other 30% are covered by oxygen burning (Guppy et al).

Cancerous tumors consist of compounds of unicells reflecting those in the archaic ocean (of anaerobic or facultative anaerobic property), with the only intentions of growing, eating, spreading and multiplicating.

Kremer treats cancer by starting and pushing the main actors of the ‚younger‘ oxygen burning system namely the mitochondrias by means of Resveratrol, Pterostilbene, Cucurmin, Vitamin D3 (very important) and many other polyphenolic compounds.

By Gonzalez and Beard we know that phylogenetically the period of archaic unicells is embryologically reflected by the trophoblast in mammals and man (vertebrates). And in early pregnancy the foetus, invading the mother’s uterus, is ‚physiologic cancer‘, by exactly the 56th day of pregnancy (in humans) the character of a part of these cells changes dramatically into benign ones and the more outer placed ones are getting into apoptosis. That change of this ‚physiologic cancer‘ into „good“ tissue takes place when the pancreas of the embryo starts to work. The discovery of this was the beginning of the ‚pancreatic enzyme treatment of cancer‘ by means of mainly Trypsin and the other pancreatioc enzymes.

By Beard we know that in nature (plants and animals) in the process of multiplication asexual generations are always followed by sexual ones etc. (this is a rule!), the trophoblast is the asexual generation in mammals and men and when the trophoblast gives rise to primordial germ cells only one (or more than one in case of twins, triplets etc.) of those gives rise to the embryo the other ones stay aside and travel after three postfertile weeks into the back part of the yolk sac (hypoblast), multiplicating and feeding themselves tremendously and go back into the embryonic body in which meanwhile all the organs have been formed basically structured and these ‚vagrant germ cells‘ are being spread all over the embryo’s body and remain there the rest of the individual’s life, also an adequate portion of 30% gets into the gonads being bound to meiosis to make way for the following sexual generation on the cellular level.

By Beard we also do know that the (cancerous) trophoblast is growing best in an acidic environment (now we know a tumor’s matrix-metall-proteinases like it acidic), while the upcoming pancreas on day 56th of pregnancy (or postfertile?) produces pancreatic ferments or enzymes working best in an highly alkaline juice (pH 9!). The high alkalinity of the pancreatic juice is caused by the very high content of sodium bicarbonate (sive!).

By Gonzalez we know that these vagrant germ cells remainig all over our bodies are nothing else but the so called adult stem cells whose origin lies completely in the dark according to official science. These cells serve as repair and replacing cells for our tissues and they obnoxiously can occasionally form a „sibling“ of us: a cancerous tumor

By Simoncini we know that cancer behaves very much like fungus and according to him it is even one because he discovered that cancerous compounds dissolve quite well by alkalizing their extracellular interstitial space moreover he states that fungus can represent itself in so many forms science does not know yet. The best natural antimycotic is Sodiumbicarbonate.

Official oncology admitts there is always fungus with cancer but it is a secondary fungal infection. Simoncini maintains the other way, there is always fungus in the first place! I am deeply convinced Simoncini is right because there are so many positive therapeutic reports on cancer on his homepage these can’t all be faked. Moreover he has scientific predecessors HR Dr. Franz Gerlach from Mödling and the pleomorphists like Dr. Günther Enderlein in general.

Simoncini observed that the links between cancer cells get disrupted easily by alkalinity and the immune system can deal much more the better with singular cells than a compound (tumor), here it lies at hand to combine alkalinization (Simoncini) with pancreatic enzymes (Gonzalez and Beard).

C O N C L U S I O N OF THE CONCLUSION

Cancer cells are acid machines, this counts first of all for solid tumors (not necessarily in lymphomas) these are producing abundant amounts of lactic acid because 70% and more of their energy need is fed by sugar burn without oxygen. That acid on the one hand is being exported in the extracellular space right outside the cell membrane and sets a remakable activating stimulus to the matrix-metallo-proteinases that melt away the healthy surrounding tissue of the cancer patient (or the uterus tissue of the mother in case of pregnancy) and on the other the huge acidity is buffered in the cell’s inside very effectively.

The acid export can be blocked amongst other chemicals by commonly prescribed Amilorid .

First of all cancer cells do have to stand their own acidity that’s why those are intracellularly calibrated highly alkaline! This is happening through buffering by sodium bicarbonate, the crucial point is that NaHCO3 is a so called ‚open buffer‘ means the carbonic acid molecule which is formed by the buffer reaction (HCO3- + H+ = H2CO3) IN THE MOMENT is believed to fall apart into water and carbondioxide and therefore gone thus the buffer can keep a very high alkalinity without being used up too quickly. The falling apart of carbonic acid does not happen spontaneously in vital systems BUT is accelerated by the intracellular enzyme carbonic anhydrase 10 000 000 times thus the intracellular pH of the cancer cell is definitely steered by CA. Carbonic acid is chemically defined as instabile acid because of its tendency to fall apart into H2O and CO2 spontaneously in labs or open systems like alcolholic fermentation etc. BUT this is not the case in closed vital systems like the human body where ist appears as STABILE ACID.

The buffering of acidity inside the cell can be blocked by inhibiting carbonic anhydrase by acetazolamide (Diamox e.g) and other CA –blockers.

The acidic interstitial space and the further environment of a cancerous tumor has to be alkalized but not mainly by Sodiumbicarbonate but by the salt of a weak organic acid like citrate, lactate, acetate etc.

The strategy implies the cancerous tumor‘s extracellular alkalinization by intake (or iv) of organic salts and acidification intracellularly by inhibition of Carboanhydrase (and ev. the acid exporting membrane carrier).

Eventual additional application of pancreatic enzymes, Resveratrol, Cucurmin, Vitamin D3 (very important) and many polyphenolic compounds (PAC etc.) . Healthy cells are only effected minimaly (acceptable intracellular pH decrease) because they are depending mainly on oxygen burn in the mitochondrias.

How Burzynski fits into this is not yet clear.

The highly alkalizing effect of sodium bicarbonate is depending completely on the enzyme carbonic anhydrase, first you have the normal buffer reaction where the carbonate ion (HCO3-) associates with the acidic hydronium ion (H+) forming carbonic acid (H2CO3), this is completely spontaneous, but what comes now is different to other buffers that are used up rather quickly when all the buffer salt has been transformed into its acid (pH sinks dramatically).

Unlike other resulting acids carbonic acid is falling apart after buffering into carbon dioxide (CO2) and water (H2O) by action of CA, as mentioned in detail above, this means the acid is gone and this buffer is a so called „open“ one means moreover the stoichiometric balance is remaining on the left side of the chemical reaction therefore the reaction does not switch off itself (no product inhibition).

A buffer is a mixture of a weak (organic) acid and its salt(s) and each of these has its ideal pH-value in adjusting a certain liquid solution, interestingly it would be in our body in case of the carbonic acid/bicarbonate buffer a pH range of around 6,2! This is far too acidic for life! The biologic neutral point is pH 7,4! But a cancer cell’s inside is fixed in a pH range between 7,46 and even 7,60 (Kremer) to stand the tremendous amounts of lactic acid being produced.

This high intracellular alkaline calibration of the cancer cell is only possible because of (1st) the permanent export of lactic acid and H+ ions and lactate ions out of the cell and importing Na+ and bicarbonate ions into the cell, (2nd) as mentioned, the „open“ bicarbonate buffer which keeps the balance of the reaction on the left side and (3rd) the enzyme carboanhydrase that is accelerating the ‚opening‘, namely the falling apart of carbonic acid into CO2 and H2O by 10 000 000 times.

This means if you give to a cancer patient sodiumbicarbonate you are actually supporting the tumor cell‘s inside alkalinity because of the action of carboanhydrase which further means you help the cancer cell staying alive and healthy! And in the interstitial space you produce rather the contrary because carboanhydrase is mainly an intracellular and cell surface enzyme, remember without the action of carboanhydrase the carbonic acid/bicarbonate buffer adjusts nearly at pH 6,2!

I have seen many doctors (including myself) treating their cancer patients naturally having given them sodiumbicarbonate and they all failed … except Dr. Simoncini! Nobody else dares to give these large amounts of Sodiumbicarbonate and by these high dosages you are sometimes riskful to the patient especially in the weak and heavily exhausted ones after chemo (Potassium can get down very quickly).

Only by giving very huge amounts of NaHCO3 you are overruling the enzyme carboanhydrase (substrate inhibition) and this consequently leads to a carbonic acid intoxication of the cancer cell and it dies …

To miknimize the risk for patient you just have to inhibit carboanhydrase by a blocker (e.g. acetazolamide), the acid membrane carriers by amilorid and apply to the patient a pure organic buffer like lactate …

(Also citrate, acetate or succinate could be possible but I believe lactate buffer would be best because it is (probably not being endangered of getting imported to the cancer cell’s inside for buffering).

The basic testimony requires the cancer cell‘s intracellular acidification and extracellular alkalinization as it is stated above.

Never give sodiumbicarbonate alone to a cancer patient but orally for heartburn only! It is most decisive to inhibit the enyme carboanhydrase!

Moreover to make a patent of this is hardly possible because all the suggested substances are in longterm use already (‚off label‘ prescription).

Your idea of injecting sodiumbicarbonate (Simoncini) with or without proteolytic enzymes directly into the tumor is also of value though it should be done at least with some portion of lactate to support the enzymes‘ action and effect.

And generally spoken: Simoncioni’s experiences are still valid although you have to inhibit carboanhydrase first, then you need definitely smaller amounts of sodiumbicarbonate if at all.

Of course also a pure oral therapy has to be put into accountance (just swallowing baking soda, acetazolamide, enzymes etc.).

We know that cancer cells need the so called matrix-metallo-proteinases to desintegrate the surrounding tissue for growth, these enzymes work best in an acidic milieu, the model is to alkalize the tumor’s surrounding to slow down the destructive matrix-metallo-proteinases, I believe this works best by lactate because I think it cannot be „misused“ by the cancer cell for alkalizing itself‘s inside (cancer cells exporting lactate, not importing it!).

There are isotonic (0,85 or 0,9%) and isoionic (same electrolyte concentration Na+, K+, Cl- as in the serum of the blood) solutions per 500ml or cc plus a certain amount of lactate on the market (Ringer Lactate with e.g. 15 mval lactate- ion per 500ml)

If we give this 500ml iv by a butterfly needle e.g. by this we do a ‚whole body alkalizing rinse‘ of the interstitial space where alkalinity is needed the most.

The other maybe better way would be to set the butterfly needly subcutaneously in the area of the tumor because there interstitial alkalinity is strongly needed (if it’s in the colon e.g. you use the skin of the epigastrium, if it’s colorectally use the skin of the lower body etc.). If this is burning subcutaneous infiltration of the piercing point by lidocain is indicated before (1-2 ml or cc, 2% concentration, the rest put in the lactate solution)

(We don’t use sodiumbicarbonate because it is not alkalizing the interstitial space may be even acidifying it by extracellular lack of carboanhydrase and we don’t use other salts like citrate, acetate or succinate because these might be imported by the cancer cell to alkalize itself intracellularly.)

When you talk of infusion you are referring to a subcutaneous injection?. Here there are terminal cases, but the specialists do not say it and they go on and on until the patient dies. They do not die of cancer, but usually because of strokes or heart attack. The drugs used against cancer harm the patients in a great number of cases by so called side effects.
There are many patients that don‘t want to receive zytostatic toxic treatments. They are potential volunteers for this treatment.

250 mg Acetazolamide (Diamox) in the morning and

1 tablet Potassium/Magnesium-Aspartate (Tromcardin) and 1 infusion 500 ml isoionic solution plus 15mval lactate ion (Ringer‘s solution), could be also given, maybe even better, as palliative infusion subcutaneously in the region of the tumor,

if it’s burning infiltrate

1-2 ml Lidocaine 2% where you set the butterfly needle, ev. put the rest oft he ampoule into the intravenous (IV) infusion.

If this works fine after a few days or week we should give additionally

1 mg Amilorid as monosubstance e.g. in the morning, on the market it’s usually combined with Hydrochlorothiazide (HCT).

If the patient is doing well we can increase the dosage, just 20years ago there were many so called „outtreated“ patients (no more treatment options), medicine did not touch them any longer, they were waiting for dying, now thex are put on palliative care. These would be the fitting ones for this treatment.

This low dosage is on purpose because we only want to reach cancer cells that are much more sensitive (theoretically) to this kind of treatment than normal cells, we want to avoid systemic effects as far as possible.

I fit works well so far there will be sodiumbicarbonate infusion (IV or even subcutaneous) the next option.

The normal procedure is very hard for the patients. But what is true now there are many people that survive a cancer much longer more than before. One thing I have noticed is that some years ago patients were very thin before dying, now they are not. Now they look well and sometimes suddenly they are gone by paraneoplasic incidences (usually letal thromb-emboli).

I never injected SBC into tumors, I gave it iv and the results were not satisfying, many doctors still giving it iv, patients getting short of breath an then they die by the tumor … Once I discovered they are doing immediately better by giving them Ringer Lactate iv (alkalizing), thus I realized they had been acidified by the SBC which was and is actually supposed to alkalize. Here I realized further that by SBC you can „overrule“ the potency of CA (substrate inhibition) and making a patient worse and even die if you are continuing the application (inner suffocation). It’s a question of the right dosage! But I believe to give dangerous dosages of SBC is not necessary if you are inhibiting CA at the same time.

But intratumorous injections of SBC seems to be a real good solution if the tumor is accessible!

In the last 15 years when palliative care has come up more and more they developed a method of putting liquid to dehydrated (mostly terminal) patients, to avoid the more or less deteriorated arm-veins of the patient they are positioning the butterfly needle of the infusion subcutaneously (fix it by adhesive band) and let it drop …

This is a very gentle method to bring liquid to the body of the suffering, normally the abdominal wall‘s subcutaneous fat is punctured or the inner side of the thighs, although you can do it on other spots of the body as well.

In my mind we can use this to bring alkalinity to the cancer’s immediate surrounding (you are addressing the interstitial space directly!) by doing this with Ringer lactate, to prevent burning at the needle place we apply lidocain subcutaneously bevor starting, we position the needly where we think alkalinity is most advantageous. If there is no special place to figure out we use abdominal wall or the thighs at the inner side, moreover we can administer it iv nonetheless.

Sodiumbicarbonate could be of help only in very large dosages because you do need those to overrule intracellular carboanhydrase and on the cell’s surface as well, apatient having undergone chemotherapy and radiation before is very weak, high dosages of sodiumbicarbonate would probably put him or her at risk, I would recommend 1000 cc or 1000 ml isotonic and isoionic solution with approximately 30 mval or mmol L-lactate daily given subcutaneously in a region where patient is having the primary tumor but also in regions of swollen lymphnodes as well.

This solution is called Ringer’s lactate, this would be the first step, there can be no harm.

Next would be just 250mg Acetazolamide (Diamox) in the morning plus Mg- and K-aspartate (morning and evening) very simple.

The only guy who knows how to treat with high dosed NaHCO3 is Dr. Simoncini, just look on his homepage

www.curenaturalicancro.com

But I did not find any usable information on lymphoma, there is in his book „Cancer is a fungus“ though on page 186 a few words on non-Hodgkin-lymphoma, not vera encouraging.

Evidently Simoncini was not that successful in lymphomas with solely sodiumbicarbonate treatment.

The main point, science has not yet found out that all the lymphomas and leukoses are probably another type of disease as compared to solid tumors.

Or tell to the mother Dr. Gonzalez‘ homepage in New York

http://www.dr-gonzalez.com/lymphoma.htm

There is some remarkable case reports of non-Hodgkin-lymphomas.

The third way would be to get in contact with German Dr. Kremer living in Barcelona (!), give his email to the mother cellsymbiosis@telefonica.net

Many doctors and healing practitioners are following his way in Central Europe with remarkable results on cancers and AIDS but I don’t know in particular concerning lymphomas.

There are some most successful cancer doctors in the world, there are other ones too, but these ones I tried to understand means to conclude and combine their different theories.

I.) www.curenaturalicancro Simoncini in Rome: Cancer is Fungus

II.) www.dr-gonzalez.com Gonzales in NYC: Cancer is Trophoblast

III.) http://aliveandwellsf.org/kremer/ Kremer in Barcelona: Cancer is Genom A

IV.) www.burzynskiclinic.com Burzynski in Houston/Texas: Cancer is Deficiency in Negative Tumormarkers (small organic molecules named Antineoplastons)

Upcoming:

V.) (www.lifelength.com Cancer is telomeres shortening, it’s quite probable, there might be successes in the near future by either blocking and even activating telomerase.)

They have totally different theories in explaining the nature of cancer but they have one decisive fact in common: Their therapies work!

So it must be possible to create a theory unifying their cancer models, we share (hopefully) the same reality, well this I have been trying for some time with at least a model that covers all 3(4) of them.

Kremer :

More than two billions years ago there was no free oxygen (or very little) on earth, in the archaic ocean then primitive unicells and groups of unicells were floating around, these had only few basic intentions to survive and stay alive namely eating, growing and multiplicate themselves. This behavior is being ruled by probably the first genetic program nature ever developed, it’s an old archaic one, therefore called Genome A and it burns sugar without or very little oxygen; later when oxygen appeared in huger amounts on earth nature developed unicells (predecessors of our bacteries) able to utilize oxygen getting much more energy out of the burning of sugar (later these inclusions were called Mitochondrias). This bacterial genetic program is therefore called Genome B.

In a unique creational act the archaic and prebacterial cell joined somehow, these prebacteries entered the cytoplasma of the archaic unicells enabled those to utilize oxygen for burning sugar, but also the archaic Genome A remained active but dominated and overruled by the oxygen utilizing Genome B.

This act is called the act of Cell Symbiois and laid the foundation for the further development of all life on this planet.

In all living beings both gentic systems Genome A+B are still present and at work and genome B is the dominating one. What Kremer says is just as this simple, through certain unpleasant influences our mitochondrias get weaker and weaker and when this weakness reaches a certain point, Genome A takes over! And we have cancer, cancer cells are not bad they just‘re doing what they need to do for surviving.

According to Dr. Kremer Cancer is dominating Genome A caused by mitochondric failure (Mitochondriopathy). All the permanent discoveries of oncogenes is after him some kind of bullshit because each newly discoverd oncogene is nothing else but a gene or genes of Genome A.

Therapeutic consequence „GET THE MITOCHONDRIAS BACK TO WORK AGAIN“!

Kremer says, if the mitos get into trouble the cell’s ability to utilize oxygen diminishes more and more (although enough oxygen could be around „pseudohypoxia“), in fact of the cell’s need for sufficient ATP it is forced to strengthen the anarobic path for ATP-production but for the price of worsened energy economics and decreased metabolic complexity, de(!)differentiation of the cell takes place until it reaches the point of being cancerous with full activated and dominating Genome A. Kremer is being treated by his followers like a guru, he discovered a big part of the truth but not all.

These four physicians have described their methods years ago. this is why they do not mention telomerase maybe in new editions of their books or articles. Nobody can talk about cancer not to mention telomerase today. It is basic information though in fact it doesn‘t matter as long as their methods work.

Another important new information is the discovering of Resveratrol. It is a substance coming from the red wine. Researches are still discussing it, but it seems Resveratrol inhibits telomerase, reversing cancer tumors.

Sugar has also something to do with Resveratrol, because the fermentation of wine needs sugar.

So, it seems crazy, but we are taking TA-65 to activate telomerase, the enzyme of inmortality, and at the same time oncologists are trying to inhibit telomerase in cancer cells. I believe telomerase is good. I believe it is really the fountain of Youth and the prove is that they are active in babys, children and young people. But there must be a mechanism that pushes telomerase cells out of control. So, lets rule out telomerase as well. It seems it prevents cancer. So the "detonant" must be something else and telomerase start acting to heal it, but somehow there is something that obstaculize the work.

I would like to know your opinion on it and also on Resveratrol. By inhibiting telomerase, cells stop mitosis and they -in my opinion-, get "momified". Resveratrol is sold like making cells life longer, but if they can t reproduce themselves... What is the benefit?.

I am expecting the book by the italian doctor. I ll let you know when it arrives. I like Kremer very much. He seems "solid" to me.

Well, there is a quite simple thinking; cancer cells are archaic cells (the same as floating in the archaic ocean), they cannot not utilize oxygen (or a limited amount only) to burn sugar(s) that is not sufficient for surviving, so they have to burn very large amounts of sugar(s) to generate enough ATP-energy.

Our cancer cells need much much more sugar than our healthy ones (18 – 32 times!) and because there are not enough mitochondrias to change oxygen into water, it‘s even very toxic to them.

Conclusion : Sugar feeds cancer cells, oxygen kills them. Never give extra sugar(s) to cancer patients, except you have reason to believe that the cancer cells will be overeating themselves to death.

Let’s take the great mystery of terminal anorexia or cachexia of a cancer patient, they oncologists telling you, we don’t know really what actually leads to this tremendous loss of weight in the final state.

This is actually not true, the mystery of terminal cachexia has been solved for the longest by a physician named

Dr. Gold(!) http://en.wikipedia.org/wiki/Hydrazine_sulfate (look for BACKGROUND) or Dr. Gold’s Institute http://scri.ngen.com/ or himself http://www.hydrazinesulfate.org/

If you take 1 mol glucose you get 2 mol ATP, if you burn it by oxygen you get additional 18 or 32 mol ATP ( wheter it’s 18 or 32 or even yet more, literature is formally nor fully clear on that), the more metastasis or primary tumor masses the patient grows the more sugar the cancer cells need, the body starts the only way to get full supply because the patient cannot eat so much sugar or anything else, it starts Gluconeogenesis massively.

Normally Gluconeogenesis starts if the body’s blood sugar level ist getting under 60mg% (by the average), the abundant cancer cells in a terminal patient only burn oxygen up to 30% of their total energy need, the rest of 70% has to be covered by anaerobic glucolysis, means the body’s blood sugar level is permanently in the onset of getting under 60mg%, means Gluconeogenesis is being permanently switched on.

The forming os sugar has to be tremendously switched up in order to hang on or keep up with the 30% aerobic burning

First of all the patient’s cancer cells are putting all the lactic acid, that is produced by anaerobic glycolysis, out of themselves into the bloodstream which carries lactic acid to the liver that changes it into glucose again and the blood brings the newformed glucose back to the cancer cells, this is repeatedly going on and on. Moreover the body is changing all fat that is possble into glucose and all protein that is not of vital function, first total blood protein is reduced to a minimum and then the muscles and so on and on …

Dr. Gold’s method of treatment is as simple as this; he found out in experiments that there is a substance being able to block Gluconeogenesis and this is hydrazine sulphate!

HS is a MAO-blocker as being (formerly) used in depressive patients, in the moment you give this to a patient he is gaining weight almost immediately and of course the general condition improves as well.

You start with 60 mg capsules, first 1 cap in the moring after 3 days you go to 2 and after 3 days further you go to the maximum dosage of 1 cap 3 times daily, in case the patient has already a body weight under 40 – 60 kg you are going to do this by 30mg capsules.

Side effects like those of MAO-blockers, because of a certain neurotoxicity, you make a one-week-break after 4-5 weeks of intake, so the onset of neurological symptoms may be postponed.

The problem is, this substance never got approved because of its (rather acceptable) neurotoxocity (I think this was an ‚official lie‘ and does not bear the refusion), but you can get it probably somehow via the internet, there is also a number to call, I mean in case you know someone who is in the urgent need of taking it.

By this treatment there is a real chance to starve the cancer cells to death because healthy cells use oxyygen for much more effective sugar burning thus these remain untouched by the treatment.

A special ‚devilish‘ property of cancer cells relies to the fact that there is (even in cancer cells) a certain ‚oxygenic portion‘ of katabolic burning, this works like a ‚pace maker‘ forcing the anaerobic part to maximal activity.

Gonzalez

Moreover for the moment I am trying to read this book (first published 1911) by Dr. Beard (died 1924+), the other mentor of Dr. Gonzalez‘ the real pioneer of enzyme therapy and discoverer of cancer’s real cause (being germinal in origin and asexual-throphoblastic in it‘s nature).

Gonzalez did a great job by republishing it nowadays again, look www.dr-gonzalez.com http://www.newspringpress.com/beard.html or via amazon.

There is something really magnificent on Dr. Simoncini’s method in fact how it works, there is something probably he himself has not found out yet.

Resveratrol is activating some genes called silent regulators (type I and II?) and therefore called ‚sirtuins‘, there should be it‘s structural formula on wiki?

Resveratrol comes from wine and has been been used to inhibit telomerase expresion in cancer cells. Cycloastragenol is a substance coming out from astragalus and we are taking it with TA-65.

Basically everything being able to turn on the primary germ cell programm in senescent stem cells can cause cancer. Besides fungus also other microbes can do this e.g. viruses (recently a US study indicates people having oral sex quite often show more throat cancers, the scientists see viruses as cause) moreover radiation and toxins might also be able to start this devastating programm in senescent stem cells.

TA Sciences (selling TA-65) does not advice people not to take Resveratrol any longer, they did it in the beginning because of its potential telomerase inhibition effect, now they say it’s ok, there was a similar concern with cucurmin. Moreover first shortly they don’t people advice not to take TA-65 MD if they are having cancer or have had it within the last 5 years.

From my point of view, telomerase activation does not force a cell to switch on Genome A (Kremer), moreover it does not force a cell into a form of fake meiosis (Gonzalez/Beard) and it does not cause a fungal infection (Simoncini) or activate telomerase in fungal cells because these are active already. TAS says this study changed everything:

http://www.ncbi.nlm.nih.gov/pubmed/20822369

What theoretically can happen is that a benignom might eventually become a little bit larger because of the increased Hayflick limit in proliferating adult stem or persisting vagrant germ cells (fibroma, myoma, naevus, hyperostosis, meningioma, cysts, mucinoma, teratoma etc.) but these tumors don’t try to form a chorion or placenta (no need to invade the neighbouring tissue).

BTW there are several chlorine-oxygen derivatives that could eventually release Oxygen and/or its derivatives into the tissues, mostly known is ‚sodium chlorite‘ NaClO2 and its acidified form ‚chorine dioxide‘ ClO2, e.g. being used against cancer by American Biologics (Bob Bradford’s company for biologic remedies against various diseases).

Cachexia (cancerogenic slim disease) or anorexia (latin marasmus) is the final state of cancer when a patient sometimes has a body weight of 30 kg or even less in the end …

Hydrazinesulfate is a MAO-inhibitor and blocks especially glyconeogenesis.

Oxygen is very useful (by several companiey e.g. Oxychlor, MMS, Oral Oxygen etc.) remedy actually for (almost) everything, but this is a side step in our communication, we’ll be focusing on Gonzalez.

What only a few people know, O2 is the first defence against free electrons, then it’s getting degraded step by step into water, sodium bicarbonate is the main defence against free protons, then it’s degraded into CO2 and water.

Therapie mit NaHCO3 modifiziert nach Dr. W. Zöch (Theorie) & Dr. W. Surböck (Praxis)

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